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Quinolines as a suitable substance in anti-mitotic therapies in cancer


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Quinolines as a suitable substance in anti-mitotic therapies in cancer

Miriam Hancková 1 Veronika Šamšulová 2 Tatiana Betáková 1,3

1Biomedical Research Center, Slovak Academy of Sciences, Institute of Virology, Department of Viral Immunology, Dúbravská cesta 9, 845 05 Bratislava, Slovak Republic
2Palacky University Olomouc, Faculty of Science, Department of Organic Chemistry, tr. 17.listopadu 12, 771 46 Olomouc, Czech Republic
3Comenius University, Faculty of Natural Sciences, Department of Microbiology and Virology; Mlynská Dolina, Ilkovičova 6, 842 15 Bratislava, Slovak Republic
miriam.hanckova@savba.sk

At present, cancer is one of the increasing incidences causes of deaths worldwide. The basis of cancer are disturbances and alterations in molecular events within cells, e.g., uncontrolled cell proliferation, transformation or altered regulation of cell cycle. Even though many improvements have been made in the cancer therapy of various types, the searching of new substances with effective impact only towards cancer cells is still necessary. Quinolines are a heterocyclic aromatic compound that are characterized by a bicyclic core structure that is formed by a benzene ring with nitrogen atom. These organic substances have an effective biological activity, e.g. bactericidal, anti-microbial and anti-malarial [1]. However, the certain quinoline compounds present a scaffold in designing and development for new drugs useful in the treatment of various types of cancer. Several quinoline derivates are functional inhibitors of cell cycle, apoptosis, angiogenesis or cell modulation. In addition, quinoline compounds have an effective ability of structural optimalization and therefore have a strong position in modern and clinical medicine within anti-cancer therapy [2, 3]. The aim of our study was observing possible influence of quinolines to cell division that is necessary to survival of eukaryote organisms. First, we focused to synthesis and structure elucidation of new synthesized quinoline compounds. Second, we tested a biological and toxicity activities of prepared quinoline derivates to epithelial cells and analyzed also effect on tubulin polymerization in vitro what may be linked to negative or positive affect to mitotic division of cells. Outcomes of this experimental study suggest that some of prepared quinoline substances may have cytotoxic effect against cells and may affect to cell division. In addition, impact to mitotic activity can associated with formation of microtubule spindles during mitosis. Therefore, these outcomes could be contributed to discovery of new potential medicals with quinoline base and would be applied in the treatment of oncological diseases.

Keywords: cancer; treatment; quinolines; tubulin; cell division

This publication was created thanks to support under the Operational Programme Integrated Infrastructure for the project: Long-term strategic research of prevention, intervention and mechanisms of obesity and its comorbidities, IMTS: 313011V344, co-financed by the European Regional Development Fund and by the Slovak Research and Development Agency (grand No. VEGA 2/0031/20).
[1] Solomon V. R. and Lee H., Quinoline as a privileged scaffold in cancer drug discovery. Curr. Med. Chem., 2011. 18(10):
p. 1488-1508.
[2] Jain S., et al., Comprehensive review on current developments of quinoline-based anticancer agents. Arab. J. Chem., 2019. 12(8): p. 4920-4946.
[3] Musiol R., An overview of quinoline as a privileged scaffold in cancer drug discovery. Expert Opin. Drug Discov., 2017. 12(6): p. 583-597.
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? Future directions 20.05.2021 07:26
Velmi pekna praca, blahozelam k vysledkom. Aky bude "osud" vami pripravenych derivatov chinolinov, ktore sa ukazali ako perspektivne, ake planujete s nimi realizovat dalsie typy testov, v akych bio...Zobraziť celý komentár
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