Active pharmaceutical ingredients differ by their physico-chemical properties and their bioavailability therefore varies. The most frequently used and most convenient way of administration of medicines is oral, however many drugs are little soluble in water. Thus they are not sufficiently effective and suitable for such administration. For this reason a system of Lipid Based Formulations (LBF) was developed.
Series of formulations were prepared and tested in water and biorelevant media. On the basis of selection criteria, there were selected formulations with the best emulsification potential, good dispersion in the environment and physical stability. Samples of structurally different drugs included in the Class II of the Biopharmaceutics Classification System (BCS) were obtained, namely Griseofulvin, Glibenclamide, Carbamazepine, Haloperidol, Itraconazol, Triclosan, Praziquantel and Rifaximin, for testing of maximal saturation in formulations prepared from commercially available excipients. Methods were developed for preparation of formulations, observation of emulsification and its description, determination of maximum solubility of drug samples in the respective formulation and subsequent analysis.
Saturation of formulations with drugs showed that formulations 80% XA and 20% Xh, 35% XF and 65% Xh were best able to dissolve the drugs which supports the hypothesis that it is desirable to identify limited series of formulations which could be generally applied for this purpose.
Astellas Pharma Europe BV, The Netherlands IAESTE Slovakaia DVM. Denisa Toropilová, PhD.; Tom de Vringer, PhD.
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Dobrý deň
Zaujímal by ma pohľad na túto tému z hľadiska financií a ekonomiky. Aké výhody to prináša?
Ďakujem za otázku
V tejto sfére nie som celkom doma. Avšak, tieto formy liečiv prinášajú výhodu dávkovania lieku v oveľa menšej miere, ako doposiaľ existujúce liekové formy. Predpokladajú sa teda nižšie výdavky v procese výroby, ako aj pri samotnej medikamentóznej liečbe.
Ivana
Hello Ivana, I would like to ask you if the system of Lipid Based Formulations that you studied is a novel approach or had been used already. Also, have any of the modified drugs you prepared been tested for bioavailability yet? If yes, have you observed significant improvement in distribution of medications administered? Thank you for your reply :)
Re: Ivana
Thank you for the question. There are some Liquid Based Formulations which consist of Hydrophilic carrier for the drug substance (eg. Ibalgin Rapidcaps) or another forms of only one lipophilic excipient carrying a drug substance. Bioavailability of these drug substances has been studied, you can find in many databases and it is wide ranging, depending on the drug form and food administration for example. So far it was observed significant improvement just in vitro studies.